Peristaltic on-chip pump for tunable media circulation and whole blood perfusion in PDMS-free organ-on-chip and Organ-Disc systems-Reference-Cited by-同舟云学术

Peristaltic on-chip pump for tunable media circulation and whole blood perfusion in PDMS-free organ-on-chip and Organ-Disc systems

Published:2021 Issue:20 Volume:21 Page:3963-3978
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Schneider Stefan¹^ORCID,Bubeck Marvin¹²^ORCID,Rogal Julia¹³^ORCID,Weener Huub J.¹⁴^ORCID,Rojas Cristhian⁵,Weiss Martin⁵⁶,Heymann Michael²^ORCID,van der Meer Andries D.⁴^ORCID,Loskill Peter¹³⁵⁷^ORCID

Affiliation:

1. Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart, Germany

2. Institute of Biomaterials and Biomolecular Systems, University of Stuttgart, Stuttgart, Germany

3. Department of Biomedical Engineering, Faculty of Medicine, Eberhard Karls University Tübingen, Tübingen, Germany

4. Applied Stem Cell Technologies, University of Twente, Enschede, The Netherlands

5. NMI Natural and Medical Sciences Institute at the University of Tübingen, Reutlingen, Germany

6. Department of Women's Health, Faculty of Medicine, Eberhard Karls University Tübingen, Tübingen, Germany

7. 3R-Center for in vitro Models and Alternatives to Animal Testing, Eberhard Karls University Tübingen, Tübingen, Germany

Abstract

We present an Organ-Disc with integrated peristaltic pump for the closed-loop perfusion of microphysiological systems with tunable flow rates, enabling time-resolved monitoring of cell states and media properties, and the perfusion of whole blood.

Funder

Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2021/LC/D1LC00494H

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1. Microfluidic organs-on-chips

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