A DNA octahedral amplifier for endogenous circRNA detection and bioimaging in living cells and its biomarker study

Author:

Feng Rong1,Yu Shengrong12,Qian Zhiling1,Wang Yiming1,Xie Gege1,Li Bingqian1,Chen Jingwen1,Wu Yong-Xiang12ORCID,Tang Keqi12ORCID

Affiliation:

1. Institute of Mass Spectrometry, Zhejiang Engineering Research Center of Advanced Mass spectrometry and Clinical Application, School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, China

2. Zhenhai Institute of Mass Spectrometry, Ningbo, Zhejiang 315211, China

Abstract

A DNA octahedral amplifier (DOA) nanoprobe was constructed as a fluorescence assay platform for in situ FRET detection and bioimaging of circRNA in living cells.

Funder

National Natural Science Foundation of China

Key Research and Development Program of Zhejiang Province

Natural Science Foundation of Zhejiang Province

State Key Laboratory of Chemo/Biosensing and Chemometrics

Ningbo Municipal Bureau of Science and Technology

Ningbo University

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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