An experimental and computational investigation of the elusive anhydrous form of Oxyma-B-Reference-Cited by-同舟云学术

An experimental and computational investigation of the elusive anhydrous form of Oxyma-B

Published:2023 Issue:41 Volume:25 Page:5818-5826
ISSN:1466-8033
Container-title:CrystEngComm
language:en
Short-container-title:CrystEngComm

Author:

Prohens Rafel¹²^ORCID,Barbas Rafael¹^ORCID,de la Torre Beatriz G.³,Albericio Fernando⁴⁵⁶^ORCID,Frontera Antonio⁷^ORCID

Affiliation:

1. Unitat de Polimorfisme i Calorimetria, Centres Científics i Tecnològics, Universitat de Barcelona, Baldiri Reixac 10, 08028 Barcelona, Spain

2. Laboratory of Organic Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, Avda. Joan XXIII, 08028 Barcelona, Spain

3. KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban, KwaZulu-Natal 4041, South Africa

4. CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, and Department of Organic Chemistry, University of Barcelona, Martí i Franqués 1-11, 08028 Barcelona, Spain

5. Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain

6. Peptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Westville, KwaZulu-Natal 4000, South Africa

7. Departament de Química, Universitat de les Illes Balears, Crta. de Valldemossa km 7.5, 07122 Palma, Spain

Abstract

We report a combined crystallographic and computational study on the important peptide synthesis reagent Oxyma-B. It has provided deeper insight into its solid-state landscape and its tendency for hydration.

Funder

Ministerio de Ciencia e Innovación

Publisher

Royal Society of Chemistry (RSC)

Subject

Condensed Matter Physics,General Materials Science,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CE/D3CE00741C

Reference41 articles.

1. PepTherDia: database and structural composition analysis of approved peptide therapeutics and diagnostics

2. 2022 FDA TIDES (Peptides and Oligonucleotides) Harvest

3. Structural studies of reagents for peptide bond formation: Crystal and molecular structures of HBTU and HATU

4. Choosing the Right Coupling Reagent for Peptides: A Twenty-Five-Year Journey

5. tert-Butylethylcarbodiimide as an Efficient Substitute for Diisopropylcarbodiimide in Solid-Phase Peptide Synthesis: Understanding the Side Reaction of Carbodiimides with OxymaPure

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