Design, synthesis, and <i>in vitro</i> and <i>in silico</i> study of 1-benzyl-indole hybrid thiosemicarbazones as competitive tyrosinase inhibitors-Reference-Cited by-同舟云学术

Design, synthesis, and in vitro and in silico study of 1-benzyl-indole hybrid thiosemicarbazones as competitive tyrosinase inhibitors

Published:2024 Issue:39 Volume:14 Page:28524-28542
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Batool Zahra¹,Ullah Saeed²,Khan Ajmal²³,Siddique Farhan⁴,Nadeem Sumaira⁴⁵,Alshammari Abdulrahman⁶,Albekairi Norah A.⁶,Talib Rimsha¹,Al-Harrasi Ahmed²,Shafiq Zahid¹^ORCID

Affiliation:

1. Institute of Chemical Sciences, Bahauddin Zakariya University, Multan-60800, Pakistan

2. Natural and Medical Sciences Research Centre, University of Nizwa, P.O. Box 33, PC 616, Birkat Al Mauz, Nizwa, Sultanate of Oman

3. Department of Chemical and Biological Engineering, College of Engineering, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea

4. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Bahauddin Zakariya University, Multan-60800, Pakistan

5. Department of Pharmacy, The Women University, Multan, 60000, Pakistan

6. Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Post bezBox 2455, Riyadh, 11451, Saudi Arabia

Abstract

Developing new anti-tyrosinase drugs seems crucial for the medical and industrial fields since irregular melanin synthesis is linked to the resurgence of several skin conditions, including melanoma, and the browning of fruits and vegetables.

Funder

King Saud University

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA05015K

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2. Design, Synthesis, and Molecular Dynamics Simulation Studies of New Chalcone‐Based 2‐Arylidene‐1,3‐indandiones as Tyrosinase Inhibitors

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5. A novel C6-sulfonated celastrol analog as a tyrosinase and melanin inhibitor: Design, synthesis, biological evaluation and molecular simulation