Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort-Reference-Cited by-全球学者库

Unprecedented polycyclic polyprenylated acylphloroglucinols with anti-Alzheimer's activity from St. John's wort

Published:2021 Issue:34 Volume:12 Page:11438-11446
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Guo Yi¹,Huang Fang²,Sun Weiguang¹,Zhou Yuan¹^ORCID,Chen Chunmei¹,Qi Changxing¹,Yang Jing³,Li Xiao-Nian³,Luo Zengwei¹,Zhu Hucheng¹,Wang Xiaochuan²,Zhang Yonghui¹^ORCID

Affiliation:

1. Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

2. Department of Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

3. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China

Abstract

Ten PPAPs with unusual skeletons were isolated from H. perforatum. 6 represents the first multitargeted natural product that could activate PP2A and simultaneously inhibit BACE1, which highlights 6 as a promising lead compound in AD drug development.

Funder

Ministry of Education of the People's Republic of China

National Science Fund for Distinguished Young Scholars

National Outstanding Youth Science Fund Project of National Natural Science Foundation of China

Innovative Research Group Project of the National Natural Science Foundation of China

Huazhong University of Science and Technology

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/SC/D1SC03356E