Cancer–leukocyte hybrid membrane-cloaked magnetic beads for the ultrasensitive isolation, purification, and non-destructive release of circulating tumor cells

Author:

Chang Zhi-min12345,Zhang Rui56784,Yang Chao910111213,Shao Dan910111213ORCID,Tang Yuguo12345,Dong Wen-fei56784ORCID,Wang Zheng56784

Affiliation:

1. Academy for Engineering & Technology

2. Fudan University

3. Shanghai 200433

4. China

5. CAS Key Laboratory of Bio-Medical Diagnostics

6. Suzhou Institute of Biomedical Engineering and Technology

7. Chinese Academy of Sciences

8. Suzhou 215163

9. Institutes of Life Sciences

10. School of Biomedical Sciences and Engineering and National Engineering Research Center for Tissue Restoration and Reconstruction

11. South China University of Technology

12. Guangzhou International Campus

13. Guangzhou

Abstract

Most of the current circulating tumor cell (CTC) isolation techniques are based on immunomagnetic beads with antibodies or aptamers that specifically target epithelial cell adhesion molecules (EpCAMs).

Funder

National Natural Science Foundation of China

National Basic Research Program of China

Natural Science Foundation of Jiangsu Province

Jinan Science and Technology Bureau

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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