Interfering in apoptosis and DNA repair of cancer cells to conquer cisplatin resistance by platinum(iv) prodrugs

Author:

Zhang Shuren12345,Zhong Xuanmeng12345,Yuan Hao12345,Guo Yan12345,Song Dongfan12345,Qi Fen12345,Zhu Zhenzhu6758,Wang Xiaoyong910458ORCID,Guo Zijian12345ORCID

Affiliation:

1. State Key Laboratory of Coordination Chemistry

2. School of Chemistry and Chemical Engineering

3. Chemistry and Biomedicine Innovation Centre

4. Nanjing University

5. Nanjing 210023

6. School of Food Science and Engineering

7. Nanjing University of Finance & Economics

8. P. R. China

9. State Key Laboratory of Pharmaceutical Biotechnology

10. School of Life Sciences

Abstract

Platinum(iv) prodrugs targeting the DNA repair mechanism downregulate myeloid cell leukemia-1 (Mcl-1) and homologous recombination proteins (RAD51, BRCA2), thereby enhancing cytotoxicity against cisplatin-resistant cancer cells.

Funder

National Natural Science Foundation of China

Nanjing University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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