Glucuronidation of [6]-shogaol, [8]-shogaol and [10]-shogaol by human tissues and expressed UGT enzymes: identification of UGT2B7 as the major contributor-Reference-Cited by-同舟云学术

Glucuronidation of [6]-shogaol, [8]-shogaol and [10]-shogaol by human tissues and expressed UGT enzymes: identification of UGT2B7 as the major contributor

Published:2018 Issue:72 Volume:8 Page:41368-41375
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

He Liangliang¹²³⁴,Xu Jinjin¹²³⁴,Wang Qi¹²³⁴⁵,Zhang Yezi¹²³⁴,Qin Zifei¹²³⁴⁶^ORCID,Yu Yang¹²³⁴⁷,Qian Zhengming⁵⁸⁹⁴,Yao Zhihong¹²³⁴⁷^ORCID,Yao Xinsheng¹²³⁴⁷^ORCID

Affiliation:

1. College of Pharmacy

2. Jinan University

3. Guangzhou 510632

4. P. R. China

5. Key Laboratory of State Administration of Traditional Chinese Medicine

6. Department of Pharmacy

7. Guangdong Provincial Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research

8. Sunshine Lake Pharma Co., LTD

9. Dongguan

Abstract

The glucuronidation pathways of shogaols ([6]-shogaol, [8]-shogaol and [10]-shogaol) were characterized in human tissues and recombinant human UDP-glucosyltransferases, and UGT2B7 was identified as the main contributor to their glucuronidation.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2018/RA/C8RA08466A

Reference41 articles.

1. Ginger: An Ethnomedical, Chemical and Pharmacological Review

2. Neuroprotective effect of ginger on anti-oxidant enzymes in streptozotocin-induced diabetic rats

3. Antioxidant and androgenic effects of dietary ginger on reproductive function of male diabetic rats

4. Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death

5. Effects of ginger (Zingiber officinale Roscoe) on DNA damage and development of urothelial tumors in a mouse bladder carcinogenesis model

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