Identification of new bisabosqual-type meroterpenoids reveals non-enzymatic conversion of bisabosquals into <i>seco</i>-bisabosquals-Reference-Cited by-全球学者库

Identification of new bisabosqual-type meroterpenoids reveals non-enzymatic conversion of bisabosquals into seco-bisabosquals

Published:2023 Issue:35 Volume:21 Page:7141-7150
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Tong Meng-Xi¹,Duan Yong-Xia¹,Zhang Ying-Dong¹,Ye Wan-Yi¹,Qin Sheng-Ying²,Liu Xing-Zhong³,Chen Guo-Dong¹,Lv Jian-Ming¹,Hu Dan¹⁴^ORCID,Gao Hao¹^ORCID

Affiliation:

1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou 510632, China

2. Clinical Experimental Center, First Affiliated Hospital of Jinan University, Guangzhou 510630, China

3. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

4. Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

Abstract

Bisabosquals can undergo an unusual C–C cleavage through dehydration to form seco-bisabosquals. Further reaction of the ortho-phthalaldehyde group with water, ammonia, or serine leads to the production of various analogues.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Higher Education Discipline Innovation Project

Basic and Applied Basic Research Foundation of Guangdong Province

Guangdong Provincial Pearl River Talents Program

Shenzhen Institute of Synthetic Biology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link