The ruthenium complex assists in nuclear targeting and selective killing of tumor cells

Author:

Lu Yu12,Zhu Di12,Chan Liujia3,Hu Bo12,Tuohan MarMar12,Li Li12,Wang Wei45ORCID,Wang Yuji12ORCID

Affiliation:

1. Department of Medicinal Chemistry, College of Pharmaceutical Sciences of Capital Medical University, Beijing 100069, P. R. China

2. Beijing Area Major Laboratory of Peptide and Small Molecular Drugs, Engineering Research Center of Endogenous Prophylactic of Ministry of Education of China, Beijing Laboratory of Biomedical Materials, Beijing Laboratory of Oral Health, Laboratory for Clinical Medicine, Capital Medical University, Beijing 100069, P. R. China

3. School of Pharmacy, Guangxi University of Chinese Medicine, Nanning, P. R. China

4. Center for Pharmacy, University of Bergen, P. O. Box 7803, 5020 Bergen, Norway

5. Department of Chemistry, University of Bergen, P. O. Box 7803, 5020 Bergen, Norway

Abstract

NBD-Ru has dual antitumor and antimetastatic activities. Its self-assembly ability and the binding ability to transferrin assist in nuclear targeting and selective killing of tumor cells. It could realize DNA binding, thus causing cell cycle arrest.

Funder

China Scholarship Council

Beijing Municipal Commission of Education

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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