Synthesis and characterization of new 5,5′-dimethyl- and 5,5′-diphenylhydantoin-conjugated hemorphin derivatives designed as potential anticonvulsant agents-Reference-Cited by-同舟云学术

Synthesis and characterization of new 5,5′-dimethyl- and 5,5′-diphenylhydantoin-conjugated hemorphin derivatives designed as potential anticonvulsant agents

Published:2022 Issue:5 Volume:46 Page:2198-2217
ISSN:1144-0546
Container-title:New Journal of Chemistry
language:en
Short-container-title:New J. Chem.

Author:

Todorov Petar¹^ORCID,Peneva Petia¹,Georgieva Stela²,Tchekalarova Jana³,Rangelov Miroslav⁴,Todorova Nadezhda⁵

Affiliation:

1. Department of Organic Chemistry, University of Chemical Technology and Metallurgy, Sofia 1756, Bulgaria

2. Department of Analytical Chemistry, University of Chemical Technology and Metallurgy, Sofia 1756, Bulgaria

3. Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria

4. Institute of Organic Chemistry with centre of phytochemistry, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria

5. Institute of Biodiversity and Ecosystem Research, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria

Abstract

Herein, the synthesis and characterization of some novel N-modified hybrid analogues of hemorphins containing a C-5 substituted hydantoin residue as potential anticonvulsants and for the blockade of sodium channels are presented.

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Chemistry,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2022/NJ/D1NJ05235G

Reference78 articles.

1. Hemoglobin-derived peptides and mood regulation

2. Camel Hemorphins Exhibit a More Potent Angiotensin-I Converting Enzyme Inhibitory Activity than Other Mammalian Hemorphins: An In Silico and In Vitro Study

3. Novel opioid peptides defived from hemoglobin: Hemorphins

4. Family of hemorphins: co-relations between amino acid sequences and effects in cell cultures

5. Valorphin: A novel chemical structure with opioid activity

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