A responsive AIE-active fluorescent probe for visualization of acetylcholinesterase activity in vitro and in vivo

Author:

Xiang Chunbai1,Dirak Musa2ORCID,Luo Yuan1,Peng Yonglin3,Cai Lintao1ORCID,Gong Ping1,Zhang Pengfei1ORCID,Kolemen Safacan2456ORCID

Affiliation:

1. Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

2. Department of Chemistry, Koc University, 34450 Istanbul, Turkey

3. Pinete (Zhongshan) Biotechnology Co., Ltd., Digital trade building, No. 6, Xiangxing Road, Torch Development Zone, Zhongshan, 528400, China

4. Surface Science and Technology Center (KUYTAM), Koc University, 34450 Istanbul, Turkey

5. Boron and Advanced Materials Application and Research Center, Koc University, 34450 Istanbul, Turkey

6. TUPRAS Energy Center (KUTEM), Koc University, 34450 Istanbul, Turkey

Abstract

An aggregation-induced emission (AIE) active light up fluorescent probe (TCFPB-AChE) was developed for selective in vitro and in vivo imaging of acetylcholinesterase activity.

Funder

Shenzhen Fundamental Research Program

Bilim Akademisi

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,General Materials Science

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