Bioactive polyethylene synthesized by ring opening metathesis polymerization for potential orthopaedic applications

Author:

Guo Jiayi1ORCID,Park Eun Ju1,Teo Yew Chin1ORCID,Abbas Asyraf1,Goh Denise2ORCID,Smith Raymond Alexander Alfred3ORCID,Nie Yuntong4,Nguyen Hang T. L.4,Yeong Joe Poh Sheng2,Cool Simon23,Makio Haruyuki5,Teo Peili1ORCID

Affiliation:

1. Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore

2. Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Republic of Singapore

3. School of Chemical Engineering, The University of Queensland, Brisbane, QLD 4072, Australia

4. Mitsui Chemicals Singapore R&D Centre, Pte. Ltd, 50 Science Park Road, #06-08 The Kendall, Singapore 117406

5. R&D Center, Mitsui Chemicals, Inc., 580-32 Nagaura, Sodegaura, Chiba 299-0265, Japan

Abstract

Bioactive polyethylene incorporating hydrophobic PE-bearing macromonomers and hydrophilic PEGylated-peptide macromonomers was synthesized via ROMP. 3D-printed sheets of it with UHMWPE showed enhanced osteogenic activity for potential orthopaedic applications.

Funder

Institute of Materials Research and Engineering

Institute of Molecular and Cell Biology

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Polymers and Plastics,Biochemistry,Bioengineering

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