Multi-lineage heart-chip models drug cardiotoxicity and enhances maturation of human stem cell-derived cardiovascular cells-Reference-Cited by-同舟云学术

Multi-lineage heart-chip models drug cardiotoxicity and enhances maturation of human stem cell-derived cardiovascular cells

Published:2024 Issue: Volume: Page:
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Mozneb Maedeh¹²³⁴,Jenkins Amelia¹²³⁴,Sances Samuel¹,Pohlman Stephany¹²³⁴,Workman Michael J.¹,West Dylan¹,Ondatje Briana¹^ORCID,El-Ghazawi Kareem¹,Woodbury Amanda¹,Garcia Veronica J.¹,Patel Shachi¹,Arzt Madelyn¹²³⁴,Dezem Felipe⁵,Laperle Alex H.¹^ORCID,Moser V. Alexandra¹^ORCID,Ho Ritchie¹^ORCID,Yucer Nur¹,Plummer Jasmine⁵,Barrett Robert J.¹⁶,Svendsen Clive N.¹³^ORCID,Sharma Arun¹²³⁴^ORCID

Affiliation:

1. Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 127 S. San Vicente Blvd., Pavilion, Room 8405, Los Angeles, CA 90048, USA

2. Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA

3. Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA

4. Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA

5. Center for Bioinformatics and Functional Genomics, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA

6. F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA

Abstract

Cardiovascular toxicity causes adverse drug reactions and may lead to drug removal from the pharmaceutical market. We have developed a cardiac organ-chip using pluripotent stem cells to enhance cell maturity and model drug cardiotoxicity.

Funder

ALS Association

California Institute for Regenerative Medicine

Allen Institute

American Heart Association

National Institutes of Health

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2024/LC/D3LC00745F

Reference42 articles.

1. Tyrosine Kinase Inhibitors and Vascular Toxicity: Impetus for a Classification System?

2. Annual Report to the Nation on the Status of Cancer, 1975–2009, Featuring the Burden and Trends in Human Papillomavirus (HPV)–Associated Cancers and HPV Vaccination Coverage Levels

3. Tyrosine Kinase Inhibitor–Associated Cardiovascular Toxicity in Chronic Myeloid Leukemia

4. Ponatinib: Accelerated Disapproval

5. Cardiotoxicity with vascular endothelial growth factor inhibitor therapy