Triangeliphthalides A–D: bioactive phthalide trimers with new skeletons from Angelica sinensis and their production mechanism

Author:

Zou Jian12345,Chen Guo-Dong12345,Zhao Huan6345,Wang Xiao-Xia12345,Zhang Zai-Jun78345,Qu Yi-Bo910345,He Rong-Rong12345,So Kwok-Fai78345,Yao Xin-Sheng12345ORCID,Gao Hao12345ORCID

Affiliation:

1. Institute of Traditional Chinese Medicine & Natural Products

2. College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research

3. Jinan University

4. Guangzhou 510632

5. People's Republic of China

6. College of Traditional Chinese Medicine

7. Institute of New Drug Research

8. College of Pharmacy/Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases

9. GMH Institute of Central Nervous System Regeneration

10. Guangdong Medical Key Laboratory of Brain Function and Diseases

Abstract

Four bioactive phthalide trimers with new skeletons were isolated from Angelica sinensis, and their production mechanism was proposed.

Funder

National Natural Science Foundation of China

Ministry of Education of the People's Republic of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Reference19 articles.

1. Phthalides and Phthalans: Synthetic Methodologies and Their Applications in the Total Synthesis

2. L. Alejandra , D.Mayela , L. A.Jose and D.Guillermo , Progress in the Chemistry of Organic Natural Products , Springer , Berlin , 2017 , vol. 104, p. 127

3. Progress in Syntheses of 3-n-Butylphthalide and Its Analogues

4. G. Lin , S. S.Chan , H. S.Chuang and S. L.Li , Studies in Natural Products Chemistry , Elsevier , Amsterdam , 2005 , vol. 32, p. 611

5. A ligustilide dimer from angelica sinensis

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