Dihydroartemisinin engages liver fatty acid binding protein and suppresses metastatic hepatocellular carcinoma growth-Reference-Cited by-同舟云学术

Dihydroartemisinin engages liver fatty acid binding protein and suppresses metastatic hepatocellular carcinoma growth

Published:2023 Issue:19 Volume:59 Page:2747-2750
ISSN:1359-7345
Container-title:Chemical Communications
language:en
Short-container-title:Chem. Commun.

Author:

Ruan Mei-Ling¹²³,Liu Yungen⁴^ORCID,Zhang Chunlei²³^ORCID,Mao Xiaowen⁵,Hu Di²³,Lok Chun-Nam²³^ORCID,Yam Judy Wai Ping⁵^ORCID,Che Chi-Ming²³⁴^ORCID

Affiliation:

1. National Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan, 430079, P. R. China

2. State Key Laboratory of Synthetic Chemistry, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China

3. Laboratory for Synthetic Chemistry and Chemical Biology Limited, Hong Kong Science Park, Shatin, Hong Kong, P. R. China

4. Department of Chemistry, Southern University of Science and Technology, Shenzhen, Guangdong, 518055, P. R. China

5. Department of Pathology, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China

Abstract

Anti-hepatocellular carcinoma dihydroartemisinin binds FABP1 with micromolar affinity in the absence of reductive activation and acts as FABP1-dependent PPARα agonist.

Funder

Innovation and Technology Commission

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2023/CC/D3CC00265A

Reference27 articles.

1. Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture)

2. Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents

3. From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy

4. Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action

5. Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?

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