Virtual screening and in vitro validation identifies the first reported inhibitors of Salmonella enterica HPPK-Reference-Cited by-同舟云学术

Virtual screening and in vitro validation identifies the first reported inhibitors of Salmonella enterica HPPK

Published:2021 Issue:10 Volume:12 Page:1750-1756
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Müller Ronel¹,Gerwel Tiaan M.²,Kimuda Magambo Phillip³^ORCID,Bishop Özlem Tastan³,Veale Clinton G. L.¹^ORCID,Hoppe Heinrich C.⁴^ORCID

Affiliation:

1. School of Chemistry and Physics, Pietermaritzburg Campus, University of KwaZulu-Natal, Private Bag X01, Scottsville, 3209, South Africa

2. Faculty of Pharmacy, Rhodes University, Makhanda, 6140, South Africa

3. Research Unit in Bioinformatics (RUBi), Department of Biochemistry and Microbiology, Rhodes University, Makhanda, 6140, South Africa

4. Department of Biochemistry and Microbiology, Rhodes University, Makhanda, 6140, South Africa

Abstract

In this study we report the first inhibitors of Salmonella enterica HPPK. The compounds identified are structurally distinct from E.coli and S. aureus HPPK inhibitors, and offer new opportunities for expanding HPPK inhibitor space.

Funder

Inyuvesi Yakwazulu-Natali

South African Medical Research Council

Royal Society

Rhodes University

South African Agency for Science and Technology Advancement

African Academy of Sciences

National Research Foundation

Government of the United Kingdom

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2021/MD/D1MD00237F

Reference42 articles.

1. Development of Bacteriostatic DNA Aptamers for Salmonella

2. Conjugation to Enterobactin and Salmochelin S4 Enhances the Antimicrobial Activity and Selectivity of β-Lactam Antibiotics against Nontyphoidal Salmonella

3. Invasive Non‐TyphiSalmonellaDisease in Africa

4. The Relationship Between Invasive NontyphoidalSalmonellaDisease, Other Bacterial Bloodstream Infections, and Malaria in Sub-Saharan Africa

5. The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017

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