Reverse anti-breast cancer drug resistance effects by a novel two-step assembled nano-celastrol medicine

Author:

Xiao Yating1,Li Xun2,Mao Jiahui3,Zheng Hong3,Ji Rui3,Wang Zhice3,Guo Mengyu4,Yuan Hui5,Anwar Arfidin2,Chen Chunying4ORCID,Liu Xingjun6,Liu Jing34

Affiliation:

1. School of Molecular Medicine, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China

2. School of Chemical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China

3. Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of Education, School of Medicine, Northwest University, Xi'an 710069, P. R. China

4. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety & CAS Center for Excellent in Nanoscience, National Center for Nanoscience and Technology of China, University of Chinese Academy of Sciences, Beijing 100190, China

5. Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China

6. Department of Endocrinology, First Hospital Affiliated to Medical College of Xi'an Jiaotong University, Xi'an, P.R. China

Abstract

CNPs synthesized by a simple and convenient method without involve any nano-carrier and toxicity organic solvent. Meanwhile, the functional CNPs with chitosan could be endocytosed by their nano-characterization to realize drug resistance reversal.

Funder

Natural Science Foundation of Beijing Municipality

Chinese Academy of Sciences

National Natural Science Foundation of China

Data Center of Management Science, National Natural Science Foundation of China - Peking University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science

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