Suppression of colonic oxidative stress caused by chronic ethanol administration and attenuation of ethanol-induced colitis and gut leakiness by oral administration of sesaminol in mice

Author:

Ohira Hideo1ORCID,Oikawa Daiki2,Kurokawa Yoichi3,Aoki Yuichi4,Omura Ayano5,Kiyomoto Kunio5,Nakagawa Wao1,Mamoto Rie1,Fujioka Yoshio1,Nakayama Toru2ORCID

Affiliation:

1. Division of Clinical Nutrition, Faculty of Nutrition, Kobe Gakuin University, Kobe 651-2180, Japan

2. Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, Sendai, Miyagi 980-8579, Japan

3. Faculty of Bioscience, Fukui Prefectural University, Fukui 910-1195, Japan

4. Tohoku University Tohoku Medical Megabank Organization, Seiryo 2-1, Sendai, Miyagi 980-8573, Japan

5. Kiyomoto Co., Ltd., 6-1633 Totoro-cho, Nobeoka, Miyazaki 889-0595, Japan

Abstract

Sesaminol may lower the risk of ethanol-related colorectal cancer by suppressing ethanol-induced oxidative stress in the colon as well as gut leakiness.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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