Injectable Diels–Alder cycloaddition hydrogels with tuneable gelation, stiffness and degradation for the sustained release of T-lymphocytes

Author:

Yan Jie1ORCID,Gundsambuu Batjargal2,Krasowska Marta3ORCID,Platts Kirsten1,Facal Marina Paula1ORCID,Gerber Cobus4,Barry Simon C.25ORCID,Blencowe Anton1ORCID

Affiliation:

1. Applied Chemistry and Translational Biomaterials (ACTB) Group, UniSA Clinical and Health Sciences, University of South Australia, Adelaide, South Australia 5000, Australia

2. Molecular Immunology, Robinson Research Institute, University of Adelaide, Adelaide, South Australia 5005, Australia

3. Surface Interaction and Soft Matter (SISM) Group, Future Industries Institute (FII), UniSA STEM, University of South Australia, Mawson Lakes, South Australia 5095, Australia

4. Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia 5000, Australia

5. Department of Gastroenterology, Women's and Children's Hospital, SA Health, Adelaide, South Australia 5006, Australia

Abstract

Highly efficient, selective and cytocompatible fulvene–maleimide cycloaddition chemistry was applied for the preparation of injectable, cell encapsulating/releasing hydrogels with tuneable gelation and degradation kinetics.

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering,General Chemistry,General Medicine

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