Application of a rhodium-catalyzed cyclization cycloaddition cascade strategy to the total synthesis of (−)-curcumol

Author:

Zhang X. X.1234,Ko R. Y. Y.564,Xie X. Q.1234,Qi W. P.1234,Li P. C.1234,Chiu P.564ORCID

Affiliation:

1. College of Pharmaceutical Sciences

2. Zhejiang University of Technology

3. Hangzhou

4. P. R. China

5. Department of Chemistry and State Key Laboratory of Synthetic Chemistry

6. The University of Hong Kong

Abstract

The first de novo total synthesis of (−)-curcumol was accomplished using a rhodium-catalyzed cyclization–cycloaddition cascade reaction as the key step.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Reference31 articles.

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2. Chemical constituents and biological research on plants in the genus Curcuma

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4. Chemical Composition of the Essential Oil from the Leaves ofCurcuma zedoariaRosc. of Indian Origin

5. Terpenoids from Curcuma wenyujin increased glucose consumption on HepG2 cells

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