Cu-catalyzed arylation of <i>S</i>-tosyl peptides with arylboronic acids-Reference-Cited by-同舟云学术

Cu-catalyzed arylation of S-tosyl peptides with arylboronic acids

Published:2024 Issue:1 Volume:11 Page:53-59
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Ying Junjie¹,Huang Jingrong¹,Liu Chenguang¹,Chen Fa-Jie¹^ORCID,Xu Chunfa¹²^ORCID,Chen Fen-Er¹³⁴^ORCID

Affiliation:

1. Institute of Pharmaceutical Science and Technology, College of Chemistry, Fuzhou University, Fuzhou, 350108, P. R. China

2. Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, P. R. China

3. Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, P. R. China

4. Shanghai Engineering Research Center of Industrial Asymmetric Catalysis of Chiral Drugs, Fudan University, 220 Handan Road, Shanghai, 200433, P. R. China

Abstract

Herein, we reported a copper-catalyzed arylation of S-tosyl peptides with arylboronic acids under mild reaction conditions. Various S-arylated cysteines and peptides were synthesized in excellent yields in both batch and flow chemistry.

Funder

National Natural Science Foundation of China

Fuzhou University

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D3QO01534C

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3. Synthesis of the Death-Cap Mushroom Toxin α-Amanitin

4. Arylation Chemistry for Bioconjugation

5. Synthesis of modified proteins via functionalization of dehydroalanine