Structure-guided engineering ofmeso-diaminopimelate dehydrogenase for enantioselective reductive amination of sterically bulky 2-keto acids-Reference-Cited by-同舟云学术

Structure-guided engineering ofmeso-diaminopimelate dehydrogenase for enantioselective reductive amination of sterically bulky 2-keto acids

Published:2018 Issue:19 Volume:8 Page:4994-5002
ISSN:2044-4753
Container-title:Catalysis Science & Technology
language:en
Short-container-title:Catal. Sci. Technol.

Author:

Cheng Xinkuan¹²³⁴⁵,Chen Xi¹²³⁴⁵^ORCID,Feng Jinhui¹²³⁴⁵,Wu Qiaqing¹²³⁴⁵^ORCID,Zhu Dunming¹²³⁴⁵^ORCID

Affiliation:

1. University of Chinese Academy of Sciences

2. Beijing 100049

3. PR China

4. National Engineering Laboratory for Industrial Enzymes and

5. Tianjin Engineering Research Center of Biocatalytic Technology

Abstract

Structure-guided reshaping the substrate-binding pocket of ameso-diaminopimelate dehydrogenase (StDAPDH) led to a mutant W121L/H227I, which catalyzed the enantioselective reductive amination of some sterically bulky 2-keto acids.

Funder

Natural Science Foundation of Tianjin Municipal Science and Technology Commission

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Catalysis

Link

http://pubs.rsc.org/en/content/articlepdf/2018/CY/C8CY01426D

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