Synthesis, in silico, in vitro evaluation of furanyl- and thiophenyl-3-phenyl-1H-indole-2-carbohydrazide derivatives as tubulin inhibitors and anticancer agents-Reference-Cited by-同舟云学术

Synthesis, in silico, in vitro evaluation of furanyl- and thiophenyl-3-phenyl-1H-indole-2-carbohydrazide derivatives as tubulin inhibitors and anticancer agents

Published:2024 Issue:7 Volume:15 Page:2483-2495
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Saruengkhanphasit Rungroj¹²^ORCID,Ngiwsara Lukana³^ORCID,Lirdprapamongkol Kriengsak²³^ORCID,Chatwichien Jaruwan¹⁴^ORCID,Niwetmarin Worawat¹^ORCID,Eurtivong Chatchakorn⁵^ORCID,Kittakoop Prasat¹²⁶^ORCID,Svasti Jisnuson³^ORCID,Ruchirawat Somsak¹²⁷^ORCID

Affiliation:

1. Program in Chemical Sciences, Chulabhorn Graduate Institute, 54 Kamphaeng Phet 6, Talat Bang Khen, Lak Si, Bangkok 10210, Thailand

2. Center of Excellence On Environmental Health and Toxicology (EHT), OPS, Ministry of Higher Education, Science, Research and Innovation, Bangkok, Thailand

3. Laboratory of Biochemistry, Chulabhorn Research Institute, Bangkok, 10210, Thailand

4. Chulabhorn Royal Academy, Bangkok 10210, Thailand

5. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, 447 Si Ayutthaya Road, Ratchathewi, Bangkok 10400, Thailand

6. Laboratory of Natural Products, Chulabhorn Research Institute, Bangkok 10210, Thailand

7. Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, Bangkok 10210, Thailand

Abstract

Novel derivatives of furanyl-3-phenyl-1H-indole-carbohydrazide and thiophenyl-3-phenyl-1H-indole-carbohydrazide were synthesised and evaluated for their antiproliferative and tubulin inhibition activities.

Funder

Thailand Science Research and Innovation

Chulabhorn Royal Academy

Chulabhorn Research Institute

Mahidol University

Office of the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00210E

Reference57 articles.

1. The tubulin code and its role in controlling microtubule properties and functions

2. Microtubules as a target for anticancer drugs

3. Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

4. Drugs that target dynamic microtubules: A new molecular perspective