Hydroxy-β-sanshool isolated from Zanthoxylum piperitum (Japanese pepper) shortens the period of the circadian clock

Author:

Tomita Tatsunosuke1ORCID,Kawano Yasuhiro1ORCID,Kassai Masahiro2,Onda Hiroyuki2,Nakajima Yoshihiro3ORCID,Miyazaki Koyomi1ORCID

Affiliation:

1. Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Higashi 1-1-1, Tsukuba 305-8566, Japan

2. S&B Foods Inc., #605 MITSUI LINK-Lab Shinkiba1 Shinkiba 2-3-8, Koto-ku, Tokyo 136-0082, Japan

3. Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Hayashicho 2217-14, Takamatsu, 761-0395, Japan

Abstract

We showed that an ethanol extract from Zanthoxylum piperitum can shorten the circadian rhythm at the cellular level and that this activity was due to hydroxy-β-sanshool, a secondary metabolite in this plant.

Funder

Japan Society for the Promotion of Science

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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