Charge reversal hairpin peptide modified synergy therapeutic nanoplatforms for tumor specific drug shuttling

Author:

Fan Zhechen1,Ji Zhongsheng1,Zhang Feng1,Luo Peng1,Zhang Huaqing1,Zhou Jianping1,Cheng Hao1,Ding Yang12ORCID

Affiliation:

1. State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China

2. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China

Abstract

Graphene oxide nanosheets coupled with acid sensitive “hairpin-like” cell penetrating peptides enable charge reversal in tumor microenvironment to selectively penetrate the nanosheets into tumor cells for synergetic photo-chemotherapy.

Funder

Qinglan Project of Jiangsu Province of China

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Materials Science,Biomedical Engineering

Cited by 2 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Helix-specific properties and applications in synthetic polypeptides;Current Opinion in Solid State and Materials Science;2023-10

2. CPP Functionalized Nanoparticles;CPP, Cell-Penetrating Peptides;2023

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