Epigenetic stimulation of polyketide production in Chaetomium cancroideum by an NAD+-dependent HDAC inhibitor-Reference-Cited by-同舟云学术

Epigenetic stimulation of polyketide production in Chaetomium cancroideum by an NAD+-dependent HDAC inhibitor

Published:2016 Issue:2 Volume:14 Page:646-651
ISSN:1477-0520
Container-title:Organic & Biomolecular Chemistry
language:en
Short-container-title:Org. Biomol. Chem.

Author:

Asai Teigo¹²³⁴,Morita Shuntaro¹²³⁴,Taniguchi Tohru⁵⁶⁷⁸⁴,Monde Kenji⁵⁶⁷⁸⁴,Oshima Yoshiteru¹²³⁴

Affiliation:

1. Graduate School of Pharmaceutical Sciences

2. Tohoku University

3. Sendai 980-8578

4. Japan

5. Faculty of Advanced Life Science

6. Frontier Research Center for Post-Genome Science and Technology

7. Hokkaido University

8. Sapporo 001-0021

Abstract

Exposure of the fungus Chaetomium cancroideum to an NAD⁺-dependent HDAC inhibitor, nicotinamide, enhanced the production of aromatic and branched aliphatic polyketides, which allowed us to isolate new secondary metabolites, chaetophenol G and cancrolides A and B.

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2016/OB/C5OB01595B

Reference25 articles.

1. Advances in Aspergillus secondary metabolite research in the post-genomic era

2. SMURF: Genomic mapping of fungal secondary metabolite clusters

3. Triggering cryptic natural product biosynthesis in microorganisms

4. Chemical induction of silent biosynthetic pathway transcription in Aspergillus niger

5. Epigenetic remodeling of the fungal secondary metabolome

Cited by 44 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Structural diversity of microbial secondary metabolites based on chemical epigenetic manipulation;Bioorganic Chemistry;2024-02

2. Antidiabetic Potential of a Trimeric Anthranilic Acid Peptide Isolated from Malbranchea flocciformis;Chemistry & Biodiversity;2024-01-12

3. Bacteria-induced activation of a fungal silent gene cluster is controlled by histone deacetylase Sirtuin E;2023-12-05

4. Physiological and metabolic traits of Taxol biosynthesis of endophytic fungi inhabiting plants: Plant-microbial crosstalk, and epigenetic regulators;Microbiological Research;2023-07

5. Recent Advances in Search of Bioactive Secondary Metabolites from Fungi Triggered by Chemical Epigenetic Modifiers;Journal of Fungi;2023-01-28