Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells

Author:

Vanhoutte Roeland1ORCID,Barniol-Xicota Marta1ORCID,Chiu Winston2,Vangeel Laura2,Jochmans Dirk2ORCID,De Jonghe Steven2,Zidane Hadeer3,Barr Haim M.3,London Nir4ORCID,Neyts Johan2,Verhelst Steven H. L.15ORCID

Affiliation:

1. Department of Cellular and Molecular Medicine, Laboratory of Chemical Biology, KU Leuven, Herestraat 49 box 802, 3000 Leuven, Belgium

2. Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Herestraat 49, Box 1043, 3000, Leuven, Belgium

3. Maurice and Vivienne Wohl Institute for Drug Discovery, The Nancy and Stephen Grand Israel National Center for Personalized Medicine, The Weizmann Institute of Science, Rehovot 7610001, Israel

4. Department of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel

5. AG Chemical Proteomics, Leibniz Institute for Analytical Sciences ISAS, Otto-Hahn-Str. 6b, 44227 Dortmund, Germany

Abstract

The COVID-19 pandemic has revealed the vulnerability of the modern, global society.

Funder

Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen

Rega Foundation

Bundesministerium für Bildung und Forschung

Fonds Wetenschappelijk Onderzoek

Onderzoeksraad, KU Leuven

Herculesstichting

KU Leuven

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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