Discovery and computational studies of piperidine/piperazine-based compounds endowed with sigma receptor affinity-Reference-Cited by-同舟云学术

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Discovery and computational studies of piperidine/piperazine-based compounds endowed with sigma receptor affinity

Published:2023 Issue:9 Volume:14 Page:1734-1742
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

De Luca Laura¹^ORCID,Lombardo Lisa¹,Mirabile Salvatore¹^ORCID,Marrazzo Agostino²^ORCID,Dichiara Maria²,Cosentino Giuseppe²^ORCID,Amata Emanuele²,Gitto Rosaria¹^ORCID

Affiliation:

1. Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università degli Studi di Messina, Viale Ferdinando d'Alcontres 31, 98166 Messina, Italy

2. Dipartimento di Scienze del Farmaco e della Salute, Università degli Studi di Catania, Viale Andrea Doria 6, 95125 Catania, Italy

Abstract

Discovery of potent S1R agonist by means of screening campaign and analysis of binding interactions.

Funder

Ministero dell’Istruzione, dell’Università e della Ricerca

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/MD/D3MD00291H

Reference37 articles.

1. Sigma-1 Receptors in Depression: Mechanism and Therapeutic Development

2. The Molecular Function of σ Receptors: Past, Present, and Future

3. Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective

4. In vitro and in vivo sigma 1 receptor imaging studies in different disease states

5. Discovery and development of brain-penetrant 18F-labeled radioligands for neuroimaging of the sigma-2 receptors

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1. Exploring Structural Requirements for Sigma-1 Receptor Linear Ligands: Experimental and Computational Approaches;Journal of Chemical Information and Modeling;2024-06-28

2. Design, Synthesis, and Cytotoxic Assessment of New Haloperidol Analogues as Potential Anticancer Compounds Targeting Sigma Receptors;Molecules;2024-06-06

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