Molecular networking-guided investigation of the secondary metabolome of four Morus species and their in vivo neuroprotective potential for the mitigation of Alzheimer's disease

Author:

Hegazi Nesrine M.1ORCID,Mohamed Tarik A.2ORCID,Salama Abeer3,Hamed Ahmed R.2,Saad Hamada H.14,Saleh Ibrahim A.2,Reda Eman H.5,Elsayed Ahmed A. A.6,Ibrahim Mahmoud A. A.78ORCID,Paré Paul W.9ORCID,Efferth Thomas10,Hegazy Mohamed-Elamir F.2

Affiliation:

1. Phytochemistry and Plant Systematics Department, National Research Centre, 33 El-Bohouth St, Dokki, Giza 12622, Egypt

2. Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St, Dokki, Giza 12622, Egypt

3. Pharmacology Department, National Research Centre, 33 El-Bohouth St, Dokki, Giza 12622, Egypt

4. Department of Pharmaceutical Biology, Pharmaceutical Institute, Eberhard Karls University of Tübingen, 72074 Tübingen, Germany

5. Phytochemistry Laboratory, National Organization for Drug Control and Research, Giza 12622, Egypt

6. Medicinal and Aromatic Plants Research Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, 33 El-Bohouth St, Dokki, Giza 12622, Egypt

7. Computational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt

8. School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa

9. Department of Chemistry & Biochemistry, Texas Tech University, Lubbock, TX 79409, USA

10. Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences Chemistry, Johannes Gutenberg University, Staudinger Weg 5, 55128 Mainz, Germany

Abstract

Neuroprotective effects of Morus speices for the mitigation of Alzeheimer's Disease and investigation of their secondary metabolome diversity.

Publisher

Royal Society of Chemistry (RSC)

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