Metabolomics-derived biomarkers for biosafety assessment of Gd-based nanoparticle magnetic resonance imaging contrast agents

Author:

Xu Chen12,Sun Jie3,Zhang Chenhao1,Yang Lu1,Kan Hong12ORCID,Zhang Daguang4,Xue Guan4,Dong Kai12ORCID

Affiliation:

1. College of Chinese Medicinal Materials, Jilin Agricultural University, 2888 Xincheng Street, Changchun 130118, Jilin, China

2. National & Local Joint Engineering Research Center for Ginseng Breeding and Development, Changchun 130118, China

3. School of Chemical Engineering, Changchun University of Technology, Changchun 130012, China

4. Department of Orthopaedics, The First Hospital of Jilin University, Changchun 130021, China

Abstract

We employed an ultra-high performance liquid chromatography–electrospray ionization quadrupole time-of-flight mass spectrometry-based metabolomics approach to investigate the potential toxicity of Gd-based nanoparticle MRI contrast agents.

Funder

National Natural Science Foundation of China

Jilin Provincial Scientific and Technological Development Program

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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