Concise synthesis of (<i>R</i>)-reticuline and (+)-salutaridine by combining early-stage organic synthesis and late-stage biocatalysis-Reference-Cited by-同舟云学术

Concise synthesis of (R)-reticuline and (+)-salutaridine by combining early-stage organic synthesis and late-stage biocatalysis

Published:2023 Issue:36 Volume:14 Page:9863-9871
ISSN:2041-6520
Container-title:Chemical Science
language:en
Short-container-title:Chem. Sci.

Author:

Cigan Emmanuel¹^ORCID,Pletz Jakob¹,Berger Sarah A.¹,Hierzberger Bettina¹,Grilec-Zlamal Michael¹,Steiner Alexander¹,Oroz-Guinea Isabel¹,Kroutil Wolfgang¹²^ORCID

Affiliation:

1. Institute of Chemistry, University of Graz, NAWI Graz, BioTechMed Graz, Heinrichstrasse 28/II, 8010, Graz, Austria

2. Field of Excellence BioHealth, University of Graz, 8010 Graz, Austria

Abstract

Designing an alternative access to the morphinan scaffold by taking advantage of biocatalysis for asymmetric CN reduction and oxidative C–C bond formation.

Funder

Karl-Franzens-Universität Graz

Austrian Centre of Industrial Biotechnology

Österreichische Forschungsförderungsgesellschaft

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/SC/D3SC02304D

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5. THE SYNTHESIS OF MORPHINE

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