Synthesis and biological evaluation of capsaicin analogues as antioxidant and neuroprotective agents-Reference-Cited by-全球学者库

Synthesis and biological evaluation of capsaicin analogues as antioxidant and neuroprotective agents

Published:2023 Issue:46 Volume:13 Page:32150-32159
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Xie Mao¹,Wu Huixian¹²,Bian Jing³,Huang Shutong²,Xia Yuanzheng³,Qin Yujun³,Yan Zhiming¹²^ORCID

Affiliation:

1. Department of Otolaryngology-Head & Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

2. Pharmaceutical College, Guangxi Medical University, Nanning, Guangxi, China

3. Jiangsu Key Laboratory of Bioactive Natural Product Research, State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China

Abstract

We designed and synthesized a novel series of capsaicin analogues, and explored their utility for antioxidant and neuroprotective agents.

Funder

Natural Science Foundation of Guangxi Zhuang Autonomous Region

Specific Research Project of Guangxi for Research Bases and Talents

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Education

Guangxi Medical University

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA05107B

Reference38 articles.

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2. Research progress of capsaicin responses to various pharmacological challenges

3. Capsaicin: A “hot” KDM1A/LSD1 inhibitor from peppers

4. Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress