Improved tumour delivery of iron oxide nanoparticles for magnetic hyperthermia therapy of melanoma <i>via</i> ultrasound guidance and <sup>111</sup>In SPECT quantification-Reference-Cited by-同舟云学术

Improved tumour delivery of iron oxide nanoparticles for magnetic hyperthermia therapy of melanoma via ultrasound guidance and ¹¹¹In SPECT quantification

Published:2024 Issue: Volume: Page:
ISSN:2040-3364
Container-title:Nanoscale
language:en
Short-container-title:Nanoscale

Author:

Patrick P. Stephen¹^ORCID,Stuckey Daniel J.¹^ORCID,Zhu Huachen¹,Kalber Tammy L.¹^ORCID,Iftikhar Haadi²,Southern Paul²³,Bear Joseph C.⁴^ORCID,Lythgoe Mark F.¹^ORCID,Hattersley Simon R.³^ORCID,Pankhurst Quentin A.²³^ORCID

Affiliation:

1. Centre for Advanced Biomedical Imaging (CABI), Department of Medicine, University College London, London WC1E 6DD, UK

2. Healthcare Biomagnetics Laboratory, University College London, 21 Albemarle Street, London, W1S 4BS, UK

3. Resonant Circuits Limited, 21 Albemarle Street, London, W1S 4BS, UK

4. School of Life Science, Pharmacy & Chemistry, Kingston University, Penrhyn Road, Kingston upon Thames, KT1 2EE, UK

Abstract

We increased the accuracy of tumour nanoparticle delivery using real-time ultrasound imaging and slow syringe-pump controlled infusion. This minimises off-target side effects for better and safer melanoma treatment using magnetic hyperthermia.

Funder

Wellcome Trust

University College London

Rosetrees Trust

Medical Research Council

Brain Tumour Charity

Cancer Research UK

British Heart Foundation

Engineering and Physical Sciences Research Council

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/NR/D4NR00240G

Reference83 articles.

1. Thermal dose requirement for tissue effect: experimental and clinical findings

2. The Effects of Localized Heat on the Hallmarks of Cancer

3. Selective heat sensitivity of cancer cells. Biochemical and clinical studies

4. Normal human cells at confluence get heat resistance by efficient accumulation of HSP72 in nucleus

5. Excised Human Neoplastic Tissues Are More Sensitive to Heat than the Adjacent Normal Tissues