Comparative analysis of aligned and random amniotic membrane-derived cryogels for neural tissue repair

Author:

Sousa Joana P. M.12ORCID,Deus Inês A.2,Monteiro Cátia F.2,Custódio Catarina A.23ORCID,Stratakis Emmanuel4ORCID,Mano João F.2ORCID,Marques Paula A. A. P.15ORCID

Affiliation:

1. TEMA – Centre for Mechanical Technology and Automation, Department of Mechanical Engineering, University of Aveiro, 3810-193, Aveiro, Portugal

2. CICECO – Department of Chemistry, University of Aveiro, Campus Universitario de Santiago, Aveiro 3810-193, Portugal

3. Metatissue, PCI Creative Science Park Aveiro Region, Via do Conhecimento, 3830-352 Ílhavo, Portugal

4. Institute of Electronic Structure and Laser, Foundation for Research and Technology-Hellas (FORTH-IESL), Heraklion, Greece

5. LASI – Intelligent Systems Associate Laboratory, Portugal

Abstract

Aligned cryogels made from human amniotic membrane-derived proteins with photoresponsive groups boosted neural stem cell proliferation, infiltration, and differentiation compared to random cryogels, suggesting neural tissue engineering potential.

Funder

H2020 Future and Emerging Technologies

Fundação para a Ciência e a Tecnologia

Publisher

Royal Society of Chemistry (RSC)

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