The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

Author:

Han Hai-Hao1234ORCID,Wang Han-Min23ORCID,Jangili Paramesh5ORCID,Li Mingle5ORCID,Wu Luling6ORCID,Zang Yi27ORCID,Sedgwick Adam C.8ORCID,Li Jia234ORCID,He Xiao-Peng1910ORCID,James Tony D.611ORCID,Kim Jong Seung5ORCID

Affiliation:

1. Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Rd., Shanghai 200237, P. R. China

2. State Key Laboratory of Drug Research, Molecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

3. University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, P. R. China

4. Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, P. R. China

5. Department of Chemistry, Korea University, Seoul 02841, Republic of Korea

6. Department of Chemistry, University of Bath, Bath, BA2 7AY, UK

7. Lingang laboratory, Shanghai 201203, China

8. Chemistry Research Laboratory, University of Oxford, Mansfield Road, OX1 3TA, UK

9. The International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China

10. National Center for Liver Cancer, Shanghai 200438, China

11. School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China

Abstract

This tutorial review provides a general overview for the design of prodrugs and activatable phototherapeutics which enables the development of improved therapies.

Funder

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Natural Science Foundation of Shanghai

Fundamental Research Funds for the Central Universities

China Postdoctoral Science Foundation

Henan Normal University

National Research Foundation of Korea

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemistry

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