Concise synthesis of pyrrolo[3,4-c]quinolines via a P(NMe2)3-catalyzed [4 + 2] annulation followed by a Zn/AcOH-mediated reduction–hydroamination

Concise synthesis of pyrrolo[3,4-c]quinolines via a P(NMe₂)₃-catalyzed [4 + 2] annulation followed by a Zn/AcOH-mediated reduction–hydroamination–isomerization

Published:2024 Issue:10 Volume:11 Page:2762-2767
ISSN:2052-4129
Container-title:Organic Chemistry Frontiers
language:en
Short-container-title:Org. Chem. Front.

Author:

Chen Zhengyang¹,Xiong Dan¹,Wang Nengzhong¹²^ORCID,Zhang Yufei¹,Yao Hui¹^ORCID,Zhang Jinkun³,Huang Nianyu¹²^ORCID,Zou Kun¹

Affiliation:

1. Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang Hubei 443002, China

2. Hubei Three Gorges Laboratory, Yichang Hubei 443007, China

3. The First College of Clinical Medical Science, China Three Gorges University, Yichang Hubei 443002, China

Abstract

A P(NMe2)3-catalyzed [4 + 2] annulation of 2-amino-β-nitrostyrenes and β′-acetoxy allenoates followed by a Zn/AcOH-mediated reduction–hydroamination–isomerization has been developed.

Funder

National Natural Science Foundation of China

Higher Education Discipline Innovation Project

Natural Science Foundation of Hubei Province

Hubei Provincial Department of Education

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/QO/D4QO00169A

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