Hierarchically structured microchip for point-of-care immunoassays with dynamic detection ranges-Reference-Cited by-同舟云学术

Hierarchically structured microchip for point-of-care immunoassays with dynamic detection ranges

Published:2019 Issue:16 Volume:19 Page:2750-2757
ISSN:1473-0197
Container-title:Lab on a Chip
language:en
Short-container-title:Lab Chip

Author:

Mou Lei¹²³⁴⁵,Dong Ruihua¹²³⁴⁵,Hu Binfeng¹²³⁴⁵,Li Zulan⁶⁷⁸,Zhang Jiangjiang¹²³⁴⁵,Jiang Xingyu¹²³⁴⁵^ORCID

Affiliation:

1. Beijing Engineering Research Center for BioNanotechnology

2. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety

3. CAS Center for Excellence in Nanoscience

4. National Center for NanoScience and Technology

5. Beijing

6. Reproduction Center of the 306th Hospital of People's Liberation Army

7. Chaoyang District

8. P. R. China

Abstract

We report a hierarchically structured microchip combined with an automated and portable device for dynamic multiplexed immunoassays. Our system can detect multiple biomarkers from pg mL⁻¹ to μg mL⁻¹ spanning a dynamic range of 10 orders of magnitude.

Funder

National Natural Science Foundation of China

Chinese Academy of Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

Biomedical Engineering,General Chemistry,Biochemistry,Bioengineering

Link

http://pubs.rsc.org/en/content/articlepdf/2019/LC/C9LC00517J

Reference36 articles.

1. Chemiluminescence immunoassay based on microfluidic chips for α-fetoprotein

2. A microfluidic indirect competitive immunoassay for multiple and sensitive detection of testosterone in serum and urine