Comprehensive two-dimensional gas chromatography with mass spectrometry: an advanced bioanalytical technique for clinical metabolomics studies

Author:

Zaid Atiqah1,Khan Mohammad Sharif2,Yan Dandan3,Marriott Philip J.4ORCID,Wong Yong Foo1ORCID

Affiliation:

1. Centre for Research on Multidimensional Separation Science, School of Chemical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia

2. Cargill Research and Development Center, Cargill, 14800 28th Ave N, Plymouth, MN 55447, USA

3. Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia

4. Australian Centre for Research on Separation Science, School of Chemistry, Monash University, Wellington Road, Clayton, VIC 3800, Australia

Abstract

This review highlights the current state of knowledge in the development of GC × GC-MS for the analysis of clinical metabolites. Selected applications are described as well as our perspectives on current challenges and potential future directions.

Funder

Ministry of Higher Education, Malaysia

Publisher

Royal Society of Chemistry (RSC)

Subject

Electrochemistry,Spectroscopy,Environmental Chemistry,Biochemistry,Analytical Chemistry

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