Synthesis of maleimide-braced peptide macrocycles and their potential anti-SARS-CoV-2 mechanisms

Author:

Li Jian12,Sun Jina23,Zhang Xianglei4,Zhang Ruxue5,Wang Qian12,Wang Lin4,Zhang Leike5,Xie Xiong23,Li Chunpu23ORCID,Zhou Yu23ORCID,Wang Jiang23ORCID,Xiao Gengfu5,Bai Fang4,Liu Hong123ORCID

Affiliation:

1. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Avenue, Nanjing, 210023, China

2. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, China

3. University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing, 100049, China

4. Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China

5. State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, 430071, China

Abstract

A novel strategy to construct maleimide-braced macrocycles has been established. The unique macrocycles exhibited excellent anti-SARS-CoV-2 infection activity via targeting the N protein of SARS-CoV-2.

Funder

National Natural Science Foundation of China

Shanghai Science and Technology Development Foundation

China Postdoctoral Science Foundation

National Key Research and Development Program of China

Publisher

Royal Society of Chemistry (RSC)

Subject

Materials Chemistry,Metals and Alloys,Surfaces, Coatings and Films,General Chemistry,Ceramics and Composites,Electronic, Optical and Magnetic Materials,Catalysis

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