Long-term and continuous administration of Bacillus subtilis during remission effectively maintains the remission of inflammatory bowel disease by protecting intestinal integrity, regulating epithelial proliferation, and reshaping microbial structure and function

Author:

Liu Yongqiang1234,Yin Fang5674,Huang Linsheng8674,Teng Hongfei5674,Shen Tongyi5674,Qin Huanlong5674ORCID

Affiliation:

1. Department of Surgery

2. Nanjing Drum Tower Hospital

3. Nanjing 210008

4. China

5. Department of Gastrointestinal Surgery

6. Shanghai Tenth People's Hospital Affiliated to Tongji University

7. Shanghai 200072

8. Department of Pediatrics

Abstract

The long-term and continuous administration of Bacillus subtilis in remission phase could effectively maintain the remission of IBD by improving the intestinal microenvironment, particularly the gut microbiota and corresponding metabolites.

Funder

National Natural Science Foundation of China

Publisher

Royal Society of Chemistry (RSC)

Subject

General Medicine,Food Science

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