Sulfamide instead of urea in Biginelli reaction: from black box to reality

Author:

Lyapunov Alexander Yu.12,Tarnovskiy Andriy V.12,Boron Sergey Yu.1,Rusanov Eduard B.3,Grabchuk Galyna P.2,Volochnyuk Dmytro M.123,Ryabukhin Serhiy V.123ORCID

Affiliation:

1. Enamine Ltd, 78 Winston Churchill str., 02094 Kyiv, Ukraine

2. Taras Shevchenko National University of Kyiv, 60 Volodymyrska str., 01601 Kyiv, Ukraine

3. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Akademik Kuhar str., 02660 Kyiv, Ukraine

Abstract

The scope and limitations of the classical Biginelli reaction have been expanded to principally novel substrates: sulfamide and its monosubstituted analogues.

Funder

Ministry of Education and Science of Ukraine

Publisher

Royal Society of Chemistry (RSC)

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