A drug–drug cocrystal and a co-amorphous form, prepared from honokiol and ligustrazine, inspired by Chinese patent medicine
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Published:2023-11-15
Issue:6
Volume:79
Page:519-524
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ISSN:2052-5206
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Container-title:Acta Crystallographica Section B Structural Science, Crystal Engineering and Materials
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language:
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Short-container-title:Acta Crystallogr Sect B
Author:
Zhang Yanli,Liu Hui,Chen Zongxin,Meng Jialei,Li Yunfeng,Qi Luyao,Zhang Suiliang,Chen Xiaofeng,Lei Ming
Abstract
A drug–drug cocrystal created with two antithrombotic-active ingredients from herbs, honokiol (HON) and ligustrazine (TMP, 1:1), was synthesized and characterized. The structure of HON–TMP (1:1) was determined by single-crystal X-ray diffraction. Then co-amorphous HON–TMP was prepared by honey-assisted grinding, which was inspired by a grinding process for a Chinese patent medicine-Shijunzi honey pill. This co-amorphous drug–drug cocrystal (20% honey) exhibits improved solubility over HON and a significantly reduced sublimation tendency than TMP.
Funder
the Health and Family Planning Research Project of Health Committee of Shanghai Pudong New Area
National Natural Science Foundation of China
Open Fund of the Key Laboratory of Emergency and Trauma Research of the Ministry of Education
Construction of Shanghai Municipal Health and Health Commission East China Area and Municipal TCM Specialty Alliance
Publisher
International Union of Crystallography (IUCr)
Subject
Materials Chemistry,Metals and Alloys,Atomic and Molecular Physics, and Optics,Electronic, Optical and Magnetic Materials