Affiliation:
1. Kuban State Medical University
Abstract
Introduction. The study of the influence of environmental toxicants on the incidence of allergic diseases is a significant medical and social problem.Aim. To study the frequency and characteristics of allergic pathology in patients with multiple chemical sensitivity syndrome (MCH).Materials and methods. Using the QEESI questionnaire, 468 outpatients undergoing a preventive medical examination were surveyed (232 men, mean age 34.2 ± 9.3 years and 236 women, mean age 42.9 ± 13.8 years). Statistical processing was carried out using the statistical program MedCalc. The relationships and differences in the indicators were considered statistically significant at p < 0.05.Results. The frequency of MCH was 211 people (45.1%). Allergic diseases were found in the study in 21.0% (102) of patients: allergic rhinitis in 24 (44.4%), asthma in 13 (22.2%), food allergy in 9 (16.6%), atopic dermatitis in 8 (14.8%) patients. Significant differences in the subscale of the effect on life were revealed in patients with bronchial asthma (p = 0.01), food allergies (p = 0.01), atopic dermatitis (p = 0.01). The average scores on all points in patients with MCH and allergic diseases were significantly higher than in the group with isolated MCH syndrome (p = 0.01). Among patients with allergies, the number of women was significantly higher (74.9% vs. 25.1%, p = 0.01), women more often had high scores for each of the three subscales compared with men: 25% vs. 10% (p = 0.001) for chemical intolerance, 29% vs. 10% (p = 0.001) in terms of severity of symptoms and 22% versus 5% (p = 0.001) in terms of impact on life.Conclusion. 25.6% of patients with HCV had allergic diseases: asthma, allergic rhinitis, food allergies, and atopic dermatitis. Significant differences in the subscale of life effects in patients with bronchial asthma, food allergies and atopic dermatitis were revealed.