Metabolic therapy in the treatment of cardiovascular diseases

Author:

Kopylova V. S.1ORCID,Boronovskiy S. E.1ORCID,Sokolova L. P.2ORCID,Mashkovtseva E. V.3ORCID,Nartsissov Ya. R.4ORCID

Affiliation:

1. Institute of Cytochemistry and Molecular Pharmacology

2. Pirogov Russian National Research Medical University

3. Institute of Cytochemistry and Molecular Pharmacology; Pirogov Russian National Research Medical University

4. Institute of Cytochemistry and Molecular Pharmacology; Biomedical Research Group, BiDiPharma GmbH

Abstract

Today, cardio- and cerebrovascular diseases pose a severe threat to human health and life quality, leading to reduced working capacity, disability and, often, death. The most common cardiovascular diseases are arterial hypertension, chronic cerebral ischemia and ischemic heart disease. Metabolic disorders that cause oxidative stress growth, vessel wall damage, and injury of body cells and tissues, as well as affect energy formation processes are the key aspects of their formation. Glutathione is a powerful antioxidant that protects cell structures from damage by free radicals, helping to reduce oxidative stress. Eltacin has a corrective effect on these pathological processes, rising the antioxidant protection of the body by increasing the efficiency of glutathione-dependent mechanisms of cell redox regulation. As a result of the complex impact on metabolic processes in the tissue, Eltacin has not only antioxidant, but also neuro- and cytoprotective and vegetotropic effects. The drug has a positive effect on the hemodynamic performance of patients with cardiovascular diseases, which is expressed in blood flow normalization in the heart as well as in the brain. The inclusion of Eltacin in traditional therapy for cardiovascular diseases patients leads to an increase in the antianginal and hypotensive effects. Its use in combined treatment regimens contributes to structural and functional state improvement of the myocardium of the left ventricle, which is a key factor for maintaining normal heart functioning. Increased physical activity tolerance allows patients to lead a more active lifestyle, which has a beneficial effect on their overall condition and life quality. In addition, the vegetotropic effectiveness of Eltacin has been proven. It results in meteoprotective effect, which reduces weather factors influence on the hemodynamics of weather-dependent patients with arterial hypertension and ischemic heart disease. Thus, Eltacin not only improves the condition of patients and increases traditional therapy effectiveness, but also provides additional protection from adverse environmental influence.

Publisher

Remedium, Ltd.

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