Clinical impact of molecular genetic testing in pediatric oncology

Author:

Dinikina Yu. V.1ORCID,Imyanitov E. N.2ORCID,Suspitsin E. N.2ORCID,Zheludkova O. G.3ORCID,Nikitina I. L.1ORCID,Belogurova M. B.1ORCID

Affiliation:

1. Almazov National Medical Research Centre

2. Petrov National Medical Cancer Research Centre

3. Voino-Yasenetsky Scientific and Practical Center for Specialized Medical Care

Abstract

Despite remarkable progress in the management of pediatric oncological diseases they remain one of the leading causes of mortality. The disease progression due to tumor resistance, treatment-induced toxic effects and infections complications may contribute to the lethality. New diagnostic technologies facilitate the identification of clinically significant genetic alterations for individualization of therapy approach in order to increase its effectiveness, reduce associated toxicity and improve quality of life of patients and their families. The most promising diagnostic approach is based on next-generation sequencing and includes targeted-, whole exome- and genome sequencing of patients’ blood DNA and tumor tissue. Despite the low rate of detected pathogenic alterations, some of them have prognostic significance, determine sensitivity to anticancer agents and targeted therapy. Moreover, targeted therapy in some cancer types shows benefit over standard therapeutic options. The application of targeted therapy in pediatric patients poses more challenges than in adults. This is due to the absence of established doses, regimens and indications for targeted agents in pediatric clinical trials, risks of associated toxicity and its high cost. This paper summarizes the data on molecular genetic markers, which are potentially helpful in guiding therapy for cancer in children.

Publisher

Remedium, Ltd.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3