The role of phytocomponents in the complex therapy of chronic non-calculous cholecystitis

Abstract

Non-calculous  cholecystitis is a form of cholecystitis caused  by dysfunction  or hypokinesis of the gallbladder. The polyetiology and multiplicity of the pathogenesis of this disease  requires  different  approaches to its correction. In this situation, phytopreparations containing components of origin provide special  attention in combination with the main therapy. Curcumin has a strong protective  effect against  cholestasis through farnesoid X receptors, resulting  in a release of bile acid homeostasis and counteracting inflammatory  inflammation and as a manifestation of cholestasis. Several studies  show that  curcumin requires a contraction of the gallbladder. Despite the presence of many useful properties,  the widespread use of curcumin in medical practice was limited by its limited bioavailability. Forms with increased bioavailability have been synthesized, such as kavacarcumin. The use of artichoke leaf extract  in gastroenterology is based on its strong antidyspeptic effect, mediated by choleretic activity. As study  show, the  choleretic effect  of the  artichoke  was  more  pronounced than  that  of the  reference drug. In the  description,  there  is no direct effect  of chamomile  phytocomponents on the  state  of bile compatibility  and the  function of bile outflow, however, an indirect effect on its work is possible. The results  make chamomile  flower extract  a good addition to therapy. Thus, due to the occurrence  of synergistic components, the complex is found in individuals, in patients with chronic diseases  of the biliary tract, with functional  disorders, the period of treatment in long-term complex therapy, with the prevention  of exacerbation and prolongation of remission, as well as in healthy individuals for the prevention of these  diseases.