Azilsartan Attenuates Lesion Area of Thermally-Induced Burn in Rats: A Comparative Study with Silver Sulfadiazine

Abstract

Objective: To explore the beneficial effects of azilsartan in rat models of burn wounds. Methods: Forty male rats were divided into four groups: The negative control group (NC) of 4 animals was used as a control. Positive control group (PC), azilsartan-treated group (AZ), and silver-sulfadiazine group (SV). Each group consisted of twelve rats with burn injuries, subdivided into three subgroups each of four (euthanized on days 7, 14, and 21 post-burn injury induction). Results: The levels of RBC, platelets, and HGB in the treated groups did not vary significantly. The AZ group had significantly greater WBC levels, while the AZ and SV groups had significantly higher lymphocyte levels than the PC group. After 7 days of treatment, both the PC and AZ groups showed a significant improvement in lesions and burn area, but the SV group showed no significant improvement. The improvement was considerable after 14 days of treatment in the SV-treated group and the AZ group, with no meaningful changes evident after 7 days of treatment in either of the indicated groups. When compared to the initial day of induction, no significant reduction was found in the PC group after 7 and 14 days of treatment. After 21 days of induction, the control group showed a considerable reduction in lesion and burn area. On the last day of treatment, however, the AZ and SV groups showed a more dramatic decline. Conclusions: Azilsartan heals the burnt area effectively, which could be related to limiting the local effects of Ag II, and deserves to be evaluated in a clinical environment.