Effect of Grape Seed Proanthocyanidins Supplement on the Incidence of Recurrent Urinary Tract Infections in a Sample of Iraqi Diabetic Patients

Abstract

Background: Proanthocyanidin is often used to prevent urinary tract infections (UTIs) in susceptible E. coli strains. Objective: To explore how grape seed proanthocyanidin extract (GSPE) affects type 2 diabetic patients (T2DM) with recurrent urinary tract infections (rUTIs). Method: The efficacy of GSPE in the treatment of T2DM with rUTIs was assessed in this randomized, single-blind controlled study. Sixty adults with diagnosed T2DPs and urinary tract infections were randomly assigned to treatment for 12 weeks with metformin (0.5 g t.i.d.) in Group A (Control Group) and a combination of GSPE (300 mg q.d.) and metformin (0.5 g t.i.d.), Group B, with the end of follow-up being 24 weeks, according to the study. Results: The medicinal plant GSPE reduces the recurrence of urinary tract infections in patients with T2DM after 12 weeks of treatment, compared with pre-treatment values and the control group. After 12 weeks of treatment for T2DM, fasting plasma glucose levels, creatinine, urea, and uric acid in both groups decreased non-significantly compared to control. There were fewer recurrent UTIs in the intervention group (77.8%), the control group (48.1%), and the GSPE (7.1%), compared to the control group (12.7%), the GSPE (7.1%), and the intervention group (33.7%) over the course of 24 weeks. Conclusions: Utilizing GSPE to treat, prevent, and minimize recurrent urinary tract infections in T2DM will help them better grasp the benefits and hazards associated with the daily administration of an appropriate GSPE dose.