Serum β-hCG Levels in Pregnant Women with Mild and Severe Preeclampsia During the Third Trimester

Abstract

Background: Preeclampsia is a prevalent complication that frequently arises during pregnancy. It is a disorder of the trophoblasts. Given that human chorionic gonadotropin is secreted by the trophoblast, this complication may have an impact on its serum concentration. Objective: To compare the β-hCG levels of expectant women who are preeclamptic and those who are normotensive. Methods: A prospective cross-sectional study design was implemented at Al-Elweyia Maternity Teaching Hospital for this investigation. One hundred fifty expectant women in their third trimester are participating. The study participants were allocated into three cohorts, each consisting of 50 women: normotensive, mild preeclamptic, and severe preeclamptic. β-hCG levels in maternal serum were determined using an enzyme-linked immunosorbent assay (ELISA) in every instance. Results: Compared to expectant women with normotensive conditions and patients with mild preeclampsia, the levels of maternal serum β-hCG were significantly elevated in patients with severe preeclampsia. β-hCG levels were not significantly affected by maternal age across all three groups. Conclusion: β-hCG concentrations are greater in pregnant women with moderate and severe preeclampsia compared to normotensive women, with severe preeclampsia being more pronounced than mild.